![]() While a large number of studies failed to identify the biological target of ataluren, it was discovered to bind and stabilize firefly luciferase, thus explaining the mechanism by which it created a false positive effect on the read through assay. Caution should be used with drugs that induce UGT1A9, or that are substrates of OAT1, OAT3, or OATP1B3. Interactions Īminoglycosides should not be given to someone taking ataluren, as they interfere with its mechanism of action. ![]() More than 10% of people taking ataluren in clinical trials experienced vomiting more than 5% experienced diarrhea, nausea, headache, upper abdominal pain, and flatulence between 1% and 5% of people experienced decreased appetite and weight loss, high levels of triglycerides, high blood pressure, cough, nosebleeds, abdominal discomfort, constipation, rashes, pain in their arms, legs, and chest muscles, blood in their urine, urinary incontinence, and fever. People who are pregnant or breast feeding should not take ataluren. It was designed by PTC Therapeutics.Ītaluren is used in the European Union to treat people with Duchenne muscular dystrophy who have a nonsense mutation in the dystrophin gene, can walk, and are more than five years old. Ataluren, sold under the brand name Translarna, is a medication for the treatment of Duchenne muscular dystrophy.
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